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The work investigates positive allosteric modulators (PAMs) of the GABAB receptor that bind to the heterodimeric interface between transmembrane.
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Insets are AUCinsulin and AUCglucose during the 50 minutes after glucose or arginine injection in wild-type mice (open bars) and in PAC1–/– mice (filled bars). Classic.
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PAC1 receptor–deficient mice display impaired insulinotropic response to glucose and reduced glucose tolerance · Françoise Jamen, , Bo Ahrén, Philippe Brabet.
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