Akwesasne Mohawk Casino, Hogansburg · State Route 37 ; Buffalo Raceway Hamburg Gaming, Hamburg · South Park Avenue ; Casino Empire City Yonkers. Visit Seneca Buffalo Creek Casino for thrilling gaming, sports betting and great restaurants. Enjoy drinks and cocktails at choice of bars. Seneca Buffalo Creek Casino is a Native American casino in Buffalo, New York and is open daily 24 hours. Seneca Buffalo Creek Casino in Buffalo, NY features over slot machines, table games, great restaurants, and a laidback vibe. Just blocks from Canalside, HarborCenter, the Cobblestone District, KeyBank Center, Coca-Cola® Field, the Theatre District, Larkin Square and all other. . Complete casino information including address, telephone number, map, gaming tables, slot machines. - See traveler reviews, candid photos. Top 10 Best Casinos Near Buffalo, New York · Seneca Buffalo Creek Casino · Seneca Niagara Resort & Casino · Hamburg Fairgrounds · Casino Niagara · Buffalo Creek. Buffalo Creek Casino in Buffalo, New York. Seneca Niagara Resort & Casino: Probably the best casino + hotel choice in the Niagara Falls area. If you're seeking the thrill of the game, Seneca Niagara is the place for you. Come here to have fun! The 2 established casinos in Buffalo (Buffalo Creek Seneca Casino and Buffalo Casino & Raceway Hamburg) naturally have an array of slot machines on top of. The casino's 67, square foot gaming space. We offer over 80 tables of live-action gaming plus more than 2, slot machines.